What directly causes the damage during an active Mycobacterium tuberculosis infection?

Question

Quizplus · Accepted Answer

During an active Mycobacterium tuberculosis infection, the body's immune system mounts a cell-mediated inflammatory response, which directly causes damage to lung tissue. This response is responsible for the formation of granulomas, which can lead to tissue destruction and scarring. While Mycobacterium tuberculosis can grow within macrophages, this is not the primary cause of damage during active infection. There is no known cytolysin or exotoxin produced by Mycobacterium tuberculosis that targets alveolar macrophages or heart muscle, respectively.

What Directly Causes the Damage During an Active Mycobacterium Tuberculosis