The patient is placed under general anesthesia for a carotid endarterectomy.During the surgery,the patient develops muscle contracture with skeletal muscle rigidity,acidosis,and elevated temperature.A possible cause for malignant hyperthermia is

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Individuals with polymorphisms in the ryanodine receptor gene (RYR1)at chromosome 19q13.1 are at risk of a rare pharmacogenetic condition known as malignant hyperthermia.In affected individuals,exposure to inhalation anesthetics and depolarizing muscle relaxants during general anesthesia induces life-threatening muscle contracture with skeletal muscle rigidity,acidosis,and elevated temperature.Warfarin is being researched as a variant in the VKOR1 gene and in the cytochrome P450 enzyme CYP2C9 gene.

The Patient Is Placed Under General Anesthesia for a Carotid