A direct immunofluorescent antibody (DFA)test was performed on a sputum sample that yielded a positive test.The organism grew on BCYE medium and was a thin gram-negative,faintly staining bacillus.What is the drug of choice for this organism?

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Because newer agents such as fluoroquinolones and the newer macrolides (e.g. ,clarithromycin,azithromycin)are more active against Legionella pneumophila,erythromycin has been replaced.Alternative regimens include doxycycline and the combination of erythromycin and rifampin.Clinical response usually follows within 48 hours after the introduction of effective therapy.Penicillins,cephalosporins of all generations,and aminoglycosides are not effective and should not be used.

A Direct Immunofluorescent Antibody (DFA)test Was Performed on a Sputum