This region regulates the switching of the b-like globin chains during development.

Question

Quizplus · Accepted Answer

The locus control region (LCR) is a regulatory sequence that is responsible for coordinating the switching of globin genes during development. It is located upstream of the beta-globin cluster on chromosome 11 and is crucial for proper expression of the gamma-globin genes during fetal development, and the subsequent switching of gamma-globin to beta-globin in adults. Thus, the LCR acts as the master globin regulator, controlling the precise timing and expression of the globin genes.

This Region Regulates the Switching of the B-Like Globin Chains