What determines whether a child with a chromosome 15q11-q13 deletion will have Angelman syndrome or Prader-Willi syndrome?

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Quizplus · Accepted Answer

The parent of origin of the deletion determines whether the child will have Angelman syndrome or Prader-Willi syndrome. If the deletion is inherited from the mother, the child will have Angelman syndrome, while if it is inherited from the father, the child will have Prader-Willi syndrome. This is due to the fact that genes in this region are subject to genomic imprinting, where only one copy of the gene is expressed depending on whether it came from the mother or father.

What Determines Whether a Child with a Chromosome 15q11-Q13 Deletion