How Might Antisense Oligonucleotides Be Used to Alleviate the Severity

How might antisense oligonucleotides be used to alleviate the severity of Duchenne muscular dystrophy?

A) By causing the degradation of mutant transcripts
B) By upregulating the expression of the mutant gene
C) By blocking the transcription of the mutant gene
D) By replacing the mutant sequence
E) By blocking exon splice enhancers so that the exon containing the mutation is skipped