The drugs of choice for most enterococcal infections are:

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Enterococci are intrinsically resistant to a wide array of antimicrobial agents, and they are generally resistant to killing by any of the single agents (e.g., ampicillin, vancomycin)that are bactericidal for most other gram-positive cocci.Therefore, effective bactericidal activity can only be achieved with the combination of a cell wall-active agent, such as ampicillin or vancomycin, and an aminoglycoside, such as gentamicin or streptomycin.

The Drugs of Choice for Most Enterococcal Infections Are