In the early stages of Alzheimer's disease,the neuritic plaques and neurofibrillary tangles are largely centered in the

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The hippocampal region is typically the first area of the brain to be affected by Alzheimer's disease. This region plays a key role in memory, and the formation of neuritic plaques and neurofibrillary tangles in this area can lead to significant cognitive decline. While other areas of the brain may also be affected as the disease progresses, the hippocampus is generally the primary focus in the early stages.

In the Early Stages of Alzheimer's Disease,the Neuritic Plaques and Neurofibrillary