Selective Estrogen Receptor Modulators (SERMs) Are Known to Inhibit Bone

Selective estrogen receptor modulators (SERMs) are known to inhibit bone resorption and prevent fractures. Their mechanism of action is:

A) Decrease production of interleukins that up regulate osteoclasts
B) Promote follicular production of progesterone, prostaglandin F₂α, and proteolytic enzymes
C) Suppress the hypothalamic-pituitary axis
D) Decrease plasma calcium levels
E) Increase activity of the hypothalamic GnRH pulse generator