Many hormones are large and hydrophilic.Where would you expect the receptor proteins for these hormones to be located?

Question

Quizplus · Accepted Answer

If the hormones are hydrophilic, they cannot pass through the hydrophobic interior of the cell membrane, so the receptor proteins for these hormones need to be located on the cell membrane with the hormone-binding site exposed to the cell exterior. In this way, the hormone can bind to the receptor on the extracellular surface and trigger a cascade of intracellular signaling events to produce a response. Choice A cannot be correct as the hydrophilic hormone cannot bind to a receptor located on the interior of the cell, and choice B is unlikely as the hydrophilic hormone cannot pass through the hydrophobic portion of the cell membrane. Choice C cannot be correct as the hydrophilic hormone cannot enter the cytoplasm directly.

Many Hormones Are Large and Hydrophilic