Some Hormones,like Thyroxine,affect Most or All Body Cells,while Others Only

Some hormones,like thyroxine,affect most or all body cells,while others only affect a single organ or type of cell.This is because of variations in

A) hormone concentration-when present in high concentration, a hormone can stimulate a greater number of body locations.
B) receptor distribution-all cells or organs with receptors for the hormone will be affected.
C) membrane permeability-hydrophobic hormones enter and affect all cells, whereas hydrophilic hormones have more limited affects.
D) signal transduction-only cells with the appropriate enzymes needed to activate the hormone will respond to its signal.