Antibody-mediated responses are most effective when the B cell and pathogen are in the same tissue and have physical contact with each other.

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Antibody-mediated responses, also known as humoral immunity, are most effective against pathogens in body fluids (blood, lymph) rather than requiring direct contact between B cells and pathogens in the same tissue. B cells produce antibodies that circulate and bind to antigens, marking them for destruction or neutralization.

Antibody-Mediated Responses Are Most Effective When the B Cell and Pathogen