Bioavailabilty reduced specifically for drugs orally administered may be due to:
A) nonspecific binding.
B) Phase II biotransformation.
C) Phase I biotransformation.
D) first-pass metabolism.

Question

Quizplus · Accepted Answer

First-pass metabolism refers to the metabolism of drugs that occurs in the liver after oral administration, before the drug enters systemic circulation. This can significantly reduce the bioavailability of the drug.

Bioavailabilty Reduced Specifically for Drugs Orally Administered May Be Due