A drug metabolite that is unable to cross the blood-brain barrier to its size likely underwent:
A) a polymorphism process.
B) nonspecific binding.
C) Phase I biotransformation.
D) Phase II biotransformation.

Question

Quizplus · Accepted Answer

Phase II biotransformation involves conjugation reactions that increase the water solubility of a drug, making it easier to eliminate from the body. These reactions can add larger polar groups that may prevent a drug or its metabolites from crossing the blood-brain barrier, protecting the brain from potentially harmful substances.

A Drug Metabolite That Is Unable to Cross the Blood-Brain