The first clinically used MAO inhibitor was…

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Iproniazid was the first clinically used MAO inhibitor, initially developed as an anti-tuberculosis medication in the 1950s. It was later found to have antidepressant properties and was used for the treatment of depression before the development of selective serotonin reuptake inhibitors (SSRIs). Phenelzine is also a clinically used MAO inhibitor, but was developed and approved for use after iproniazid. Moclobemie is not a known MAO inhibitor, and tyramine is not a medication but rather a substance found in certain foods that can cause dangerous interactions with MAO inhibitors.

The First Clinically Used MAO Inhibitor Was…