A 45-year-old woman woke up in the morning with a severe headache.She did not recognize her husband of 20 years.She then experienced a grand mal seizure.Her husband called an ambulance,and she was taken to the hospital.A CT scan disclosed a large tumour,deep in the cerebrum,that crossed the midline near the corpus callosum.Necrosis was evident throughout the tumour.A brain biopsy of a portion of the tumour was done and a representative section is shown in the accompanying photomicrograph.Which one of the following is the best diagnosis?

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Glioblastomas,especially the high grade variety (WHO Grade IV),are often large and necrotic (N),and occur in the deep cerebral cortex.It is not uncommon to see bilateral involvement,as in this vignettEDespite modern chemotherapy and radiation treatment,survival statistics are still dismal,with the majority of patients dying within 1 year.

A 45-Year-Old Woman Woke Up in the Morning with a Severe