The Wife of a 55 Year Old Man Noticed That

The wife of a 55 year old man noticed that he exhibited strange behaviour such as fits of rage and moments of confusion.Together,they consulted a GP who also noticed some neurologic abnormalities such as rigidity in the upper extremities.A representative section of the brain biopsy is shown in the accompanying photomicrograph.Which one of the following is the best diagnosis?

A) Alzheimer's disease
B) Meningitis
C) Parkinson's disease
D) Dementia with Lewy bodies
E) Creutzfeldt-Jakob disease