You are studying DNA replication in human cells. You discover a mutant cell line that can carry out DNA replication,but the final product contains both RNA and DNA fragments. What enzyme is likely to be missing in this cell line?
A) flap endonuclease
B) DNA ligase
C) DNA polymerase I
D) DNA helicase

Question

You are studying DNA replication in human cells. You discover a mutant cell line that can carry out DNA replication,but the final product contains both RNA and DNA fragments. What enzyme is likely to be missing in this cell line?
A) flap endonuclease
B) DNA ligase
C) DNA polymerase I
D) DNA helicase

Quizplus · Accepted Answer

Flap endonuclease is responsible for removing RNA primers from Okazaki fragments during DNA replication. If it is missing, RNA fragments would remain in the final DNA product.

You Are Studying DNA Replication in Human Cells