What is the difference between the allosteric and torpedo models of eukaryotic transcritponal termination?
A) The allosteric model is that RNA pol II becomes destabilized after transcription of the poly A signal sequence while the torpedo model is that the polymerase is physically removed from the DNA
B) The torpedo model is that RNA pol II becomes destabilized after transcription of the poly A signal sequence while the allosteric model is that the polymerase is physically removed from the DNA
C) The allosteric model is that RNA pol II becomes destabilized after transcription of the stop codon sequence while the torpedo model is that the polymerase is physically removed from the DNA
D) The torpedo model is that RNA pol II becomes destabilized after transcription of the stop codon while the allosteric model is that the polymerase is physically removed from the DNA
E) The only difference between the two models is the proteins that are involved in removing the RNA pol II from the DNA

Question

Quizplus · Accepted Answer

The allosteric model proposes that RNA polymerase II (Pol II) undergoes a conformational change after transcribing the poly(A) signal sequence, which destabilizes the polymerase-DNA complex and leads to termination. The torpedo model, on the other hand, proposes that a protein complex known as the torpedo binds to the elongating Pol II and physically removes it from the DNA template, leading to termination.

What Is the Difference Between the Allosteric and Torpedo Models