The mechanism behind slipped-strand mispairing is:
A) short repeats allow for slippage of the RNA polymerase during transcription of the affected genes
B) short repeats allow for slippage of DNA polymerase during replication, which leads to an out-of-frame reading sequence
C) an invertible promoter slips into different reading frames
D) the genes coding for lipopolysaccharide in Gram-negative bacteria can be slipped in and out of frame
E) short repeats slip and turn genes off, but they can never be turned back on

Question

Quizplus · Accepted Answer

Slipped-strand mispairing occurs during DNA replication and is due to the slippage of DNA polymerase on short tandem repeats. This can lead to an insertion or deletion of nucleotides, resulting in a frameshift mutation and a nonfunctional protein.

The Mechanism Behind Slipped-Strand Mispairing Is