Which Statement Is Correct About Patient Tolerance to Medications

Which statement is correct about patient tolerance to medications?

A) Tolerance only develops when the patients do not take the medication as it is prescribed.
B) The patient will continually require higher doses of the drug for the same effect to be achieved.
C) The patient will require a stable dose of the medication until the drug is discontinued.
D) Tolerance occurs when the liver or kidneys are no longer able to metabolize the drug.