Which of the following statements is true concerning adverse reactions of NSAIDs?

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All NSAIDs,including celecoxib,inhibit renal prostaglandins,decrease renal blood flow,cause fluid retention,and may cause hypertension and renal failure in some patients,especially the elderly.The NSAIDs have little effect on the patient with normal kidney function;however,with renal disease,decreases in both renal blood flow and glomerular filtration rate can occur.Prostaglandin inhibitors,such as NSAIDs,can interfere with the normal protective mechanisms in the stomach and increase acid secretion,causing symptoms or even an ulceration or perforation.These agents are not addicting,tolerance does not develop,and no withdrawal syndrome can be induced.NSAIDs reversibly inhibit platelet aggregation because they inhibit thromboxane A₂ production.In contrast to aspirin,their effect remains only as long as the drug is present in the blood: 1 day for ibuprofen,4 days for naproxen,and 2 weeks for oxaprozin.

Which of the Following Statements Is True Concerning Adverse Reactions