Changes in the conformational shape of an enzyme that diminish the size of its ligand-binding pocket are likely to affect an enzyme's:
A)specificity.
B)affinity.
C)epitope.
D)specificity and affinity.

Question

Quizplus · Accepted Answer

Changes in the conformational shape of an enzyme that diminish the size of its ligand-binding pocket are likely to affect both the enzyme's specificity and affinity for its substrate. A smaller binding pocket may prevent certain substrates from binding to the enzyme, decreasing specificity. Additionally, a smaller pocket may decrease the strength of the enzyme-substrate interaction, decreasing affinity.

Changes in the Conformational Shape of an Enzyme That Diminish