A misfolded protein targeted to the proteasome will undergo:
A)unfolding using energy released by ATPases.
B)entry into the proteasome through the narrow channel in the beta channel.
C)death by a thousand cuts in the alpha subunit rings.
D)complete cleavage into its amino acid monomers.

Question

Quizplus · Accepted Answer

A misfolded protein targeted to the proteasome will undergo unfolding by ATPases that use energy to break down the protein into smaller peptides that can fit through the narrow channel in the beta subunit. The peptides are then degraded by peptidases in the alpha subunit rings. The protein is not completely cleaved into its amino acid monomers, but rather into smaller peptides.

A Misfolded Protein Targeted to the Proteasome Will Undergo