Unassembled or misfolded proteins in the RER can be damaging to the physiology of a cell and therefore are transported to the cytosol where they are degraded.This transport process is referred to as:

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The process of transporting misfolded or unassembled proteins from the RER to the cytosol for degradation is referred to as "dislocation." This mechanism involves unfolding the protein and translocating it across the membrane of the RER into the cytosol, where it can be degraded by the proteasome.

Unassembled or Misfolded Proteins in the RER Can Be Damaging