Apoptosis can be induced by a mitochondrial protein being released into the cytosol.This protein binds directly to what in the cytosol?

Question

Quizplus · Accepted Answer

The mitochondrial protein that is released into the cytosol is called cytochrome c. Cytochrome c binds directly to Apaf-1 in the cytosol to form the apoptosome, which activates caspase 9 and initiates the caspase cascade leading to apoptosis. Bax and Bcl-2 are also involved in regulating apoptosis, but they do not directly bind to cytochrome c in the cytosol. Caspase 3 is activated downstream of caspase 9 in the caspase cascade.

Apoptosis Can Be Induced by a Mitochondrial Protein Being Released