2-hydroxyglutarate is produced in cancer cells:

Question

Quizplus · Accepted Answer

The production of 2-hydroxyglutarate in cancer cells is mainly due to mutations in isocitrate dehydrogenase enzymes, which convert isocitrate to alpha-ketoglutarate in the tricarboxylic acid (TCA) cycle. The mutated enzymes instead produce 2-hydroxyglutarate, which can accumulate to high levels in cancer cells. While increased aerobic glycolysis is a hallmark of cancer, it is not the direct cause of 2-hydroxyglutarate production. There is also no evidence that 2-hydroxyglutarate is used to counteract lactate production.

2-Hydroxyglutarate Is Produced in Cancer Cells