During an immunoglobulin E-mediated (IgE)hypersensitivity reaction,what causes bronchospasm?

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Quizplus · Accepted Answer

During an IgE-mediated hypersensitivity reaction, the binding of the allergen to IgE antibodies on mast cells and basophils leads to the release of inflammatory mediators such as histamine. The histamine binds to H1 receptors on smooth muscle cells in the bronchioles, causing them to contract and resulting in bronchospasm. Bronchial edema may also contribute to the obstruction of airflow, but this is not the primary cause of bronchospasm in this type of reaction.

During an Immunoglobulin E-Mediated (IgE)hypersensitivity Reaction,what Causes Bronchospasm