What protects tumor cells within an emboli from the host defenses and facilitates attachment to vascular epithelium?

Question

Quizplus · Accepted Answer

The fibrin-platelet complex forms a protective shield around tumor cells within emboli, preventing detection and elimination by the host immune system. It also facilitates attachment to the vascular endothelium, allowing the tumor cells to establish a secondary site of growth. Macrophages and proteolytic enzymes may play a role in the later stages of metastasis, but they do not specifically protect tumor emboli or facilitate attachment to vascular epithelium. Vascular endothelial growth factor (VEGF) is involved in angiogenesis and blood vessel formation, but it does not directly protect tumor cells within emboli.

What Protects Tumor Cells Within an Emboli from the Host