Select the Most Accurate Description of Substance Dependence

Select the most accurate description of substance dependence.

A) Symptoms occur when two or more drugs affecting the central nervous system are used for their additive effects.
B) Lack of control over use.Tolerance exists.Withdrawal symptoms occur when intake is reduced or stopped.
C) Psychoactive drug use interferes with the action of competing neurotransmitters.
D) Taking a combination of drugs to weaken or inhibit the effect of another drug.