Which type(s)of mutation might lead to a threonine auxotrophic revertant?

Question

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All the choices listed (B, C, D) are types of mutations that could potentially lead to a threonine auxotrophic revertant. A base substitution is a type of point mutation, and a missense mutation is a specific kind of base substitution that results in a change in the amino acid sequence of the encoded protein. These mutations can alter the function of enzymes involved in threonine synthesis or uptake, potentially leading to a revertant phenotype.

Which Type(s)of Mutation Might Lead to a Threonine Auxotrophic Revertant