In addition to inhibiting the transpeptidation reaction in cell wall synthesis,penicillins may also destroy bacteria by

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Penicillins can stimulate proteins to form holes in the plasma membrane, causing leakage of intracellular contents and ultimately leading to bacterial cell death. This mechanism is known as the disruption of bacterial membrane integrity. However, it's worth noting that not all penicillins have this ability, and some may only work by inhibiting cell wall synthesis.

In Addition to Inhibiting the Transpeptidation Reaction in Cell Wall