Vancomycin inhibits the transpeptidation reaction in peptidoglycan biosynthesis by binding to the D-alanine-D-alanine portion of the peptidoglycan precursor, preventing the cross-linking of peptidoglycan chains. This leads to the weakening of the cell wall and ultimately causes bacterial death.

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Vancomycin

Question 26

Multiple Choice

Vancomycin

A) inhibits the transglycosylase reaction in peptidoglycan biosynthesis.
B) interferes with the action of the lipid carrier that transports peptidoglycan precursors across the plasma membrane.
C) inhibits the transpeptidation reaction in peptidoglycan biosynthesis.
D) blocks the addition of the pentapeptide chain during peptidoglycan biosynthesis.

Correct Answer: