Examine the following diagram.Which is most likely to have occurred in panel 1,depicting proliferation?

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Panel 1 depicts proliferation, which is an increase in the number of cells. The most likely cause of this is a mutation in a proto-oncogene, which can result in it becoming an oncogene and promoting cell division uncontrollably. Loss of adhesion dependence, initiation of angiogenesis, and metastasis are all later events in the development of cancer and are less likely to occur at this stage.

Examine the Following Diagram