Please read the clinical scenario, and then answer the question that follow to become familiar with the traditional NCLEX question format.
An 18-month-old male is admitted to the hospital with symptoms of a respiratory infection. The patient’s mother reports that since birth, the toddler has frequently had a cough and copious nasal secretions. His weight gain has been poor, despite adequate oral intake. The patient appears in moderate respiratory distress, so oxygen therapy and IV fluids are initiated. The physician orders tests for cystic fibrosis due to the patient’s history and clinical presentation. When the tests confirm the diagnosis, as the RN, you provide education to the mother regarding this autosomal recessive disease.
-Which of the following terms would best describe a mutation that changes a normal codon into a stop codon?

Question

Please read the clinical scenario, and then answer the question that follow to become familiar with the traditional NCLEX question format.
  An 18-month-old male is admitted to the hospital with symptoms of a respiratory infection. The patient’s mother reports that since birth, the toddler has frequently had a cough and copious nasal secretions. His weight gain has been poor, despite adequate oral intake. The patient appears in moderate respiratory distress, so oxygen therapy and IV fluids are initiated. The physician orders tests for cystic fibrosis due to the patient’s history and clinical presentation. When the tests confirm the diagnosis, as the RN, you provide education to the mother regarding this autosomal recessive disease.
-Which of the following terms would best describe a mutation that changes a normal codon into a stop codon?

Quizplus · Accepted Answer

A nonsense mutation changes a normal codon into a stop codon, resulting in premature termination of the protein synthesis. A missense mutation changes the amino acid codon, but the protein synthesis continues. A back mutation reverts a mutated gene back to its original form. A frame shift mutation occurs when a nucleotide is inserted or deleted, causing a shift in the reading frame of the codons, resulting in a nonfunctional protein.

Please Read the Clinical Scenario, and Then Answer the Question