Which kind of enzyme prevents DNA from tangling up by introducing negative supercoils as the replication fork migrates during replication?
A)Helicase
B)Ligase
C)DNA polymerase I
D)DNA polymerase III
E)Topoisomerase

Question

Quizplus · Accepted Answer

Topoisomerase enzymes relieve the torsional stress caused by the unwinding of the DNA double helix during replication by introducing negative supercoils in the DNA strands, which helps to prevent tangling or knotting. Helicase unwinds the double helix, Ligase seals the breaks in the DNA backbone, and DNA polymerase I and III are involved in DNA synthesis.

Which Kind of Enzyme Prevents DNA from Tangling Up by Introducing