GABA Agonists, Such as Barbiturates and Benzodiazepines, Are Not Recommended

GABA agonists, such as barbiturates and benzodiazepines, are not recommended for long-term treatment of anxiety disorders because they _____ with extended use.

A) tend to cause memory loss
B) tend to produce rhythmic facial and mouth movements
C) produce tolerance and dependence
D) actually will produce the opposite effect, intensifying anxiety