The transition step, also known as the pyruvate dehydrogenase reaction, takes place in the matrix of the mitochondria and links glycolysis to the TCA cycle. During this step, pyruvate is converted to acetyl-CoA by a complex of enzymes, releasing carbon dioxide and producing reduced cofactors such as NADH. The acetyl-CoA then enters the TCA cycle to generate more ATP through oxidative phosphorylation.

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The Transition Step

Question 41

Multiple Choice

The transition step

A) links glycolysis to the pentose phosphate pathway.
B) links the pentose phosphate pathway to the Entner-Duodoroff pathway.
C) links glycolysis to the TCA cycle.
D) takes place in the matrix of the nucleus.

Correct Answer: