Arguably, the biggest blow to the mainstream economics school of thought as a way to conceptualize U.S. labor and management relations was the widespread poverty, unemployment and homelessness brought about by the Great Depression.

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The Great Depression challenged mainstream economics' ability to fully understand and address issues related to labor and management relations, as many people suffered from poverty, unemployment, and homelessness during that time.

Arguably, the Biggest Blow to the Mainstream Economics School of Thought