A daughter can inherit an X-linked recessive disorder when her father is affected and her mother is a carrier.

Question

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X-linked recessive disorders are caused by mutations on genes located on the X chromosome. If a father is affected, he will pass the mutated gene to all his daughters as they inherit an X chromosome from him. If the mother is a carrier, she also has a mutated gene on one of her X chromosomes. Therefore, there is a 50% chance that each daughter will inherit the mutated gene from her mother, making her affected or a carrier herself. Sons have a 50% chance of inheriting the mutated gene from their mother, but since they only have one X chromosome, they will be affected if they inherit the mutated gene.

A Daughter Can Inherit an X-Linked Recessive Disorder When Her