Prader-Willi and Angelman syndromes both arise from the same area of chromosome 15,illustrating

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Prader-Willi and Angelman syndromes both arise from the same area of chromosome 15 due to genomic imprinting, which results in different expression of genes depending on whether they are inherited from the mother or father. In Prader-Willi syndrome, the genes inherited from the father in this chromosome region are deleted or unexpressed, while in Angelman syndrome, the genes inherited from the mother are deleted or unexpressed. This leads to different clinical manifestations despite arising from the same chromosomal region.

Prader-Willi and Angelman Syndromes Both Arise from the Same Area