In a form of early-onset Alzheimer disease caused by a mutation on chromosome 14,A is changed to T at the first position of codon 146,which substitutes leucine for methionine.This mutation is a _______ and is __________.
A) transversion; nonsense
B) transversion; missense
C) transition; missense
D) transition; nonsense
E) transcondition; antisense

Question

Quizplus · Accepted Answer

The mutation is a transversion because it involves a change from a purine (A) to a pyrimidine (T). It is a missense mutation because it results in the substitution of one amino acid (leucine) for another (methionine).

In a Form of Early-Onset Alzheimer Disease Caused by a Mutation