By the Beginning of the 20^th Century,a Greater Percentage of Americans

By the beginning of the 20^th century,a greater percentage of Americans were dependent on opioids than at any time before or since.Opium smoking and medical use of injected pure morphine were important contributors to this,along with

A) intravenous use of heroin.
B) the growth of organized crime syndicates.
C) patent medicines containing opium extracts or morphine.
D) alcohol prohibition.