Which of the following occurs when hemoglobin switches from the T (deoxy)state to the R (oxy)state? A)the heme group goes from a slightly puckered conformation to a flat conformation B)the ferrous ion is pulled into the plane of the heme group C)the F8 (proximal)histidine rotates about 8^$\circ$ to better align with the ferrous ion D)movement of the F8 histidine causes a shift in the F helix, thus weakening interactions with other subunits E)all of the above

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All of the options listed occur when hemoglobin switches from the T (deoxy)state to the R (oxy)state. The heme group goes from a slightly puckered conformation to a flat conformation, the ferrous ion is pulled into the plane of the heme group, the F8 (proximal)histidine rotates about 8F1F1F1S1F1F1F10 to better align with the ferrous ion, and movement of the F8 histidine causes a shift in the F helix, thus weakening interactions with other subunits, which complete the whole process of oxyhemoglobin formation.

Which of the Following Occurs When Hemoglobin Switches from the T