In sickle cell hemoglobin, a Glu is mutated to a _______. This causes the formation of _______ between hemoglobin molecules, ultimately forming large aggregates.
A)Arg; salt bridges
B)Cys; disulfide bonds
C)Val; hydrophobic interactions
D)Pro; disrupted $\alpha$-helix, resulting in several H-bonds and salt bridges
E)none of the above

Question

Quizplus · Accepted Answer

In sickle cell hemoglobin, a glutamic acid (Glu) is mutated to a valine (Val), which causes the formation of hydrophobic interactions between hemoglobin molecules, ultimately leading to the aggregation of these molecules.

In Sickle Cell Hemoglobin, a Glu Is Mutated to a _______