Since an Enzyme Is a Catalyst, Which of the Following

Since an enzyme is a catalyst, which of the following must be true?

A) an enzyme-catalyzed reaction is always exergonic
B) enzymes increase the rate of a reaction by providing a completely alternate mechanism to the uncatalyzed reaction
C) over the course of an enzyme-catalyzed reaction, the enzyme is not changed
D) in the absence of an enzyme, the reaction that is normally catalyzed by the enzyme will not occur
E) enzyme-catalyzed reactions never reach equilibrium