In the mechanism of chymotrypsin, which of the following amino acids found in the active site is correctly defined in terms of its role in the reaction?

Question

Quizplus · Accepted Answer

Aspartic acid in the active site of chymotrypsin plays a crucial role in stabilizing the histidine residue. This stabilization is achieved through electrostatic interactions, which in turn makes histidine a stronger base. This enhanced basicity of histidine is essential for its role in the catalytic mechanism, where it acts as a base to abstract a proton from the serine residue, enabling serine to perform a nucleophilic attack on the substrate.

In the Mechanism of Chymotrypsin, Which of the Following Amino