Arsenic Poisoning by Either Arsenite or Organic Arsenical Agents Work $\alpha$

Arsenic poisoning by either arsenite or organic arsenical agents work by binding to dithiol compounds such as _________ meaning that in addition to inactivation of pyruvate dehydrogenase, the citric acid cycle enzyme _________ would be inactivated.

A) cysteine; aconitase
B) coenzyme A; $\alpha$ -ketoglutarate dehydrogenase
C) coenzyme A; citrate synthase
D) thiamine pyrophosphate; isocitrate dehydrogenase
E) lipoic acid; $\alpha$ -ketoglutarate dehydrogenase