In the regulation of glutamine synthetase activity, an important regulatory protein, P_II exists in two states, one with UMP covalently bound (P_II-UMP), the other without (P_II). Which of the following statements regarding $\alpha$-ketoglutarate and P_II is correct? A)$\alpha$-ketoglutarate binds to P_II causing inhibition of adenylyltransferase B)$\alpha$-ketoglutarate binds to P_II causing activation of adenylyltransferase C)$\alpha$-ketoglutarate binds to P_II-UMP causing inhibition of adenylyltransferase D)$\alpha$-ketoglutarate binds to P_II-UMP causing activation of adenylyltransferase E)$\alpha$-ketoglutarate does not bind to either form of P_II

Question

Quizplus · Accepted Answer

$\alpha$-ketoglutarate binds to P_II, leading to the inhibition of adenylyltransferase, which is involved in the regulation of glutamine synthetase activity.

In the Regulation of Glutamine Synthetase Activity, an Important Regulatory α\alphaα

In the Regulation of Glutamine Synthetase Activity, an Important Regulatory $\alpha$