The chemical histamine causes capillary walls to become more permeable.Excess histamine
Secretion,as might be seen in allergic responses,might lead to

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Excess histamine secretion causes capillary walls to become more permeable, which allows more fluid and proteins to leak out into surrounding tissues, leading to edema (swelling). Histamine does not cause decreased blood flow, blood clotting, or hypertension. While histamine can cause some sensations of pain, it does not directly increase pain sensation.

The Chemical Histamine Causes Capillary Walls to Become More Permeable